![]() ![]() Osteoporosis is a systemic skeletal disorder characterized by reduced bone mass, deteriorating microstructure of bone tissue, and diminished bone strength, resulting in increased vulnerability to fractures and fragility. The effect of BMI on fractures may be mainly mediated by BMD. Underweight has a protective effect on total and lumbar spine fractures in Chinese women, while obesity poses a risk factor for total, lumbar, and femoral neck fractures. Osteoporosis and osteopenia were identified as risk factors for almost all sites of fracture when compared to normal bone mass. Underweight was found to be a risk factor for other types of fracturess after adjusting for BMD (OR = 2.29 95% CI, 1.09 – 4.80 P < 0.001). Non-linear associations were observed between BMI and fractures: A J-curve for total, lumbar, and femoral neck fractures, and no statistical change for other types of fractures. Bone mineral density (BMD) was almost lower in the fracture groups compared to the control groups ( p = 0.048 to < 0.001). There were 2296 (74.1%) vertebral fractures, 374 (12.1%) femoral neck fractures, and 428 (13.8%) other types of fractures in the case group. ![]() Participants were classified into underweight (BMI < 18.5 kg/m 2), normal weight (18.5 ≤ BMI < 24.0 kg/m 2), overweight (24 ≤ BMI < 28 kg/m 2) and obese (BMI ≥ 28 kg/m 2) according to the Chinese BMI classification standard. Both of them underwent assessment using dual-energy X-ray absorptiometry (DXA), with BMD measurements calculated using our own BMD reference database. Three thousand ninety-eight female patients with radiographic fractures and 3098 age- and sex-matched healthy controls without fractures were included in the study. To investigate the association between BMI and osteoporotic fractures at different sites in Chinese women. ![]() Limited knowledge exists regarding this association in native Chinese, particularly utilizing local databases as reference sources. The association between body mass index (BMI) and osteoporotic fractures varies by fracture site and ethnicity. Osteoporotic fractures are a growing problem in an aging society. ![]()
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